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Take control of the metabolic stress

In the ICU & PICU

Why MDoloris Medical Systems in the ICU ?

MDoloris technology allows displaying two indexes; the ANI, which is related to the parasympathetic activity, and the Energy, which represent the global ANS activity. Displayed continuously on the monitor as a single number, it measures the patient's vital energy, in other words the reserves of biological mediators that the patient can still mobilise.
Both indexes are useful in ICU:


The ANI (NIPE) index in order to monitor patient comfort during the numerous interventional procedures in ICU, including mechanical ventilation and sedation, in order to better adapt opioid administration


The Energy value, as in pilot studies, Energy values in ICU were found to be directly correlated with days of survival: the lower the energy, the shorter the days of survival

The ANI offer continuous & non-invasive measures of the sympathic / Parasympathetic balance allowing titration of analgesics.
When compared with the SOFA scale, preliminary findings on Covid-19 patients strongly support that MDoloris Energy measurement (SDNN) can predict mortality with more specificity and sensitivity in many type of patient, particularly in sepsis patients.

ANI INDEX helps to improve analgosedation protocol in the ICU

Excessive analgosedation in both the critically ill and the surgical patient can lead to significant depletion of the sympathetic nervous system, and ultimately to greater complications and worse disease outcome.

The benefits of an analgosedation protocol


reduction of sedatives


decrease length of stay


decrease time on ventilation

Energy index helps to improve patient assessment in ICU patients

The patients with greater severity and mortality showed higher sympathetic depletion with a predominance of relative parasympathetic activity.
MDoloris Technology, and more specifically the Energy value, seems to be a non-invasive and more effective way of assessing survival than the SOFA scale, which can be useful as a triage tool or as a continuous monitoring system to inform therapeutic decisions. Autonomic nervous system and heart rate variability monitoring in critically ill patients with COVID-19 allows for predicting survival days and 30-day mortality through the Energy value.
” The SOFA score is an international scale, widely used, and currently considered the gold standard for predicting multiorgan failure in critically ill patients with sepsis. It is a multiparametric scale, which requires laboratory analytical parameters which are often not available at the patient's bedside. Our findings suggest that the Energy (SDNN) can predict mortality with more specificity and sensitivity in this type of patient when it is compared with the SOFA scale.”


Prospective multicenter study of heart rate variability with ANI monitor as predictor of mortality in critically ill patients with COVID-19 Cristian Aragón-Benedí et al , Sci Rep. 2022; 12: 21762.

Proven benefits for you and your patient

Predict hemodynamic reactivity
Assessment of comfort
Predict post-extubation pain
Diagnose the etiology of haemodynamic event